Last edited by Fegal
Tuesday, August 11, 2020 | History

5 edition of Peptide Nucleic Acids found in the catalog.

Peptide Nucleic Acids

Protocols and Applications

  • 88 Want to read
  • 39 Currently reading

Published by Horizon Press .
Written in English

    Subjects:
  • Biotechnology,
  • Genetics (non-medical),
  • Microbiology (non-medical),
  • Molecular biology,
  • Science/Mathematics,
  • Nucleic Acids,
  • Science,
  • Biochemistry,
  • Life Sciences - Biochemistry,
  • Life Sciences - Biology - General,
  • Science / Biology

  • Edition Notes

    ContributionsPeter E. Nielsen (Editor), Michael Egholm (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages276
    ID Numbers
    Open LibraryOL8728492M
    ISBN 101898486166
    ISBN 109781898486169

    Peptide Nucleic Acids, Second Edition has been extensively revised, updated, and enlarged to contain many new chapters covering the most recent topics and applications in this fast-moving field. The book contains state-of-the-art protocols and applications on . Peptide nucleic acids (PNAs) have shown great promise as potential antisense drugs; however, poor cellular delivery limits their applications. Improved delivery into mammalian cells and enhanced biological activity of PNAs have been achieved by coupling to cell-penetrating peptides (CPPs). Structural requirements for the shuttling ability of these peptides as well as structural Cited by:

    This second edition has been extensively revised, updated, and enlarged to include new material covering the most recent topics and applications in this fast-moving field. The book contains state-of-the-art protocols and applications on all aspects of Peptide Nucleic Acids (PNA) and in addition describes the theory and history of PNA. Concepts are explained clearly and in . Peptide Nucleic Acids | Exemplifying and illustrating recent exciting advances in PNA chemistry, the second edition of "Peptide Nucleic Acids: Methods and Protocols" serves as a vital complement to the first edition of the book.

    Peptide nucleic acids (PNAs) can bind duplex DNA in a sequence-targeted manner, forming a triplex structure capable of inducing DNA repair and producing specific genome modifications. Since the first description of PNA-mediated gene editing in cell free extracts, PNAs have been used to successfully correct human disease-causing mutations in cell culture and in vivo in Cited by: A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable by:


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Peptide Nucleic Acids Download PDF EPUB FB2

In Peptide Nucleic Acids: Methods and Protocols, Peter Eigil Nielsen has assembled a critically evaluated collection of PNA protocols that are either already well established around the world, such as PCR-clamping and in situ hybridization, or that display promise of Format: Hardcover.

Peptide Nucleic Acids, Second Edition has been extensively revised, updated, and enlarged to contain many new chapters covering the most recent topics and applications in this fast-moving field. The book contains state-of-the-art protocols and applications on all aspects of peptide nucleic acids.4/4(1).

Exemplifying and illustrating recent exciting advances in PNA chemistry, the second edition of Peptide Nucleic Acids: Methods and Prools serves as a vital complement to the first edition of the book.

Since Peptide Nucleic Acids book discovery of peptide nucleic acids, many interesting new derivatives and analogues in terms of nucleic acid recognition specificity and affinity have emerged.

Peptide nucleic acid (PNA) technology continues to grow in importance throughout molecular biology, genetic diagnostics, and molecular medicine. In Peptide Nucleic Acids: Methods and Protocols, Peter Eigil Nielsen has assembled a critically evaluated collection of PNA protocols that are either already well established.

Peptide Nucleic Acids: Methods and Protocols, Second Edition serves as a source of useful specific methods and protocols as well as a source of inspiration for future developments. About this book Introduction This third volume exemplifies and illustrates exciting advances in peptide nucleic acids (PNA) chemistry, and serves as a vital complement to the first and second edition of the book.

Peptide nucleic acid (PNA) technology continues to grow in importance throughout molecular biology, genetic diagnostics, and molecular medicine.

In Peptide Nucleic Acids: Methods and Protocols, Peter Eigil Nielsen has assembled a critically evaluated collection of PNA protocols that are either already well established around. The history, properties and applications of PNA in drug discovery and DNA detection is presented in the book Peptide Nucleic Acids The double helix of DNA is Nature's simple and elegant solution to the problem of storing, retrieving, and communicating the genetic information of a.

Nucleic Acids Book. A free online book on the chemistry and biology of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab.

chemical biology of peptide nucleic acids (PNA) The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications This book will be a useful resource for post-graduates seeking to gain an overview of the subject as well as for specialists in specific areas of chemical.

Peptide Nucleic Acids, Second Edition has been extensively revised, updated, and enlarged to contain many new chapters covering the most recent Reviews: 1.

PNA (Peptide Nucleic Acid) is an artificially synthesized polymer similar to DNA or RNA. The various purine and pyrimidine bases are linked to the backbone by methylene carbonyl bonds as in peptides.

Since PNA contains no charged phosphate groups, the binding between PNA and DNA is stronger than that between DNA and DNA due to the lack of. Peter Eigil Nielsen has assembled a critically evaluated collection of key PNA prools that are either already well established around the world, such as PCR-clamping and in situ hybridization, or that display promise of significant future impact.

Price: $ Peptide nucleic acids (PNAs) are not oligonucleotides and not even DNA analogues, but rather DNA mimics. Chemically PNA is a pseudopeptide in which the individual nucleobase units are amino acids joined together by amide bonds (Figure Cited by: Peptide nucleic acids (PNAs) have now existed for slightly more than ten years, with the interest in and applications of this pseudopeptide DNA mimic steadily increasing during the entire period.

PNAs have rapidly attracted the attention of scientists from a diversity of fields ranging from (bio)organic and biophysical chemistry to prebiotic. Description This third volume exemplifies and illustrates exciting advances in peptide nucleic acids (PNA) chemistry, and serves as a vital complement to the first and second edition of the book.

Chapters focus on in vivo properties and behavior and applications of PNA while providing contributions on both chemistry and nucleic acid Rating: % positive.

Here, we report a new strategy for the construction of a peptide nucleic acid–microRNA nanocomplex with dual function to simultaneously suppress oncogenic microRNAs and upregulate tumor-suppressive microRNAs in target cancer cells.

This third volume exemplifies and illustrates exciting advances in peptide nucleic acids (PNA) chemistry, and serves as a vital complement to the first and second edition of the book. Chapters focus on in vivo properties and behavior and applications of PNA while providing contributions on both chemistry and nucleic acid : Get this from a library.

Peptide nucleic acids: protocols and applications. [Michael Egholm; Peter E Nielsen;] -- "Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands.

The unique. Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex structures and perform wide-ranging activities.

Although nature has evolved machinery to read the nucleic acid Cited by: 2. ISBN: OCLC Number: Description: x, pages: illustrations (some color) ; 26 cm. Contents: 1. MiniPEG-[gamma]PNA / Arunava Manna, Srinivas Rapireddy, Raman Babal and Danith H.

Ly Cyclopentane peptide nucleic acids / Ethan A. Englund, Ning Zhang, and Daniel H. Appella Chiral PNAs with constrained open-chain .Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.

This fact creates an urgent need for new and effective antimicrobials. The common strategies for antibiotic discovery are based on either modifying existing antibiotics or Author: Monika Wojciechowska, Marcin Równicki, Adam Mieczkowski, Joanna Miszkiewicz, Joanna Trylska.

Peptide nucleic acids (PNAs) are synthetic mimics of DNA in which the deoxyribose phosphate backbone is replaced by a pseudo-peptide polymer to which the nucleobases are linked.

PNAs hybridize Cited by: